<?xml version='1.0' encoding='UTF-8'?><?xml-stylesheet href="http://www.blogger.com/styles/atom.css" type="text/css"?><feed xmlns='http://www.w3.org/2005/Atom' xmlns:openSearch='http://a9.com/-/spec/opensearchrss/1.0/' xmlns:georss='http://www.georss.org/georss' xmlns:gd='http://schemas.google.com/g/2005' xmlns:thr='http://purl.org/syndication/thread/1.0'><id>tag:blogger.com,1999:blog-7847357309347623251</id><updated>2012-01-27T03:56:40.218-08:00</updated><title type='text'>Genomic Repairman</title><subtitle type='html'></subtitle><link rel='http://schemas.google.com/g/2005#feed' type='application/atom+xml' href='http://genrepair.blogspot.com/feeds/posts/default'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/7847357309347623251/posts/default?max-results=100'/><link rel='alternate' type='text/html' href='http://genrepair.blogspot.com/'/><link rel='hub' href='http://pubsubhubbub.appspot.com/'/><author><name>Jane Shawn</name><uri>http://www.blogger.com/profile/10202717642174609796</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='http://img2.blogblog.com/img/b16-rounded.gif'/></author><generator version='7.00' uri='http://www.blogger.com'>Blogger</generator><openSearch:totalResults>4</openSearch:totalResults><openSearch:startIndex>1</openSearch:startIndex><openSearch:itemsPerPage>100</openSearch:itemsPerPage><entry><id>tag:blogger.com,1999:blog-7847357309347623251.post-394775663521839982</id><published>2012-01-27T03:51:00.000-08:00</published><updated>2012-01-27T03:56:40.370-08:00</updated><title type='text'>NASA's Kepler Announces 11 Planetary Systems Hosting 26 Planets</title><content type='html'>&lt;div dir="ltr" style="text-align: left;" trbidi="on"&gt;&lt;div dir="ltr" style="text-align: left;" trbidi="on"&gt;&lt;div dir="ltr" style="text-align: left;" trbidi="on"&gt;NASA's Kepler mission has discovered 11 new planetary systems hosting 26 confirmed planets. These discoveries nearly double the number of verified Kepler planets and triple the number of stars known to have more than one planet that transits, or passes in front of, its host star. Such systems will help astronomers better understand how planets form.&lt;br /&gt;&lt;br /&gt;The planets orbit close to their host stars and range in size from 1.5 times the radius of Earth to larger than Jupiter. Fifteen of them are between Earth and Neptune in size, and further observations will be required to determine which are rocky like Earth and which have thick gaseous atmospheres like Neptune. The planets orbit their host star once every six to 143 days. All are closer to their host star than Venus is to our sun.&lt;br /&gt;&lt;br /&gt;"Prior to the Kepler mission, we knew of perhaps 500 exoplanets across the whole sky," said Doug Hudgins, Kepler program scientist at NASA Headquarters in Washington. "Now, in just two years staring at a patch of sky not much bigger than your fist, Kepler has discovered more than 60 planets and more than 2,300 planet candidates. This tells us that our galaxy is positively loaded with planets of all sizes and orbits." &lt;br /&gt;&lt;br /&gt;Kepler identifies planet candidates by repeatedly measuring the change in brightness of more than 150,000 stars to detect when a planet passes in front of the star. That passage casts a small shadow toward Earth and the Kepler spacecraft.&lt;br /&gt;&lt;br /&gt;“Confirming that the small decrease in the star's brightness is due to a planet requires additional observations and time-consuming analysis," said Eric Ford, associate professor of astronomy at the University of Florida and lead author of the paper confirming Kepler-23 and Kepler-24. “We verified these planets using new techniques that dramatically accelerated their discovery.”&lt;br /&gt;&lt;br /&gt;Each of the new confirmed planetary systems contains two to five closely spaced transiting planets. In tightly packed planetary systems, the gravitational pull of the planets among themselves causes one planet to accelerate and another planet to decelerate along its orbit. The acceleration causes the orbital period of each planet to change. Kepler detects this effect by measuring the changes, or so-called Transit Timing Variations (TTVs).&lt;br /&gt;&lt;br /&gt;&lt;a href="http://www.nasa.gov/mission_pages/kepler/multimedia/images/kepler_planets_jan_2012.html" style="background-color: #d6d6d6; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #004d93; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;"&gt;&lt;img align="Bottom" alt="The artist's rendering depicts the multiple planet systems discovered by NASA's Kepler mission" border="0" height="300" src="http://www.nasa.gov/images/content/618676main_kepler_planets_jan_2012_4x3_226-170.jpg" style="border-bottom-style: none; border-color: initial; border-image: initial; border-left-color: rgb(0, 0, 0); border-left-style: none; border-right-color: rgb(0, 0, 0); border-right-style: none; border-top-color: rgb(0, 0, 0); border-top-style: none; border-width: initial; display: block; margin-bottom: 0px; margin-left: 1px; margin-right: 5px; margin-top: 0px;" title="The artist's rendering depicts the multiple planet systems discovered by NASA's Kepler mission" width="400" /&gt;&lt;/a&gt;&lt;span style="background-color: #d6d6d6; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;&lt;/span&gt;&lt;i style="background-color: #d6d6d6; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;Click image for multiple resolutions and full caption.&lt;/i&gt;&lt;br /&gt;&lt;b style="background-color: #d6d6d6; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;Kepler's Planetary Systems&lt;/b&gt;&lt;span style="background-color: #d6d6d6; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;: The artist's rendering depicts the multiple planet systems discovered by NASA's Kepler mission.&amp;nbsp;&lt;/span&gt;&lt;br /&gt;&lt;span style="background-color: #d6d6d6; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;Image credit: NASA Ames/Jason Steffen, Fermilab Center for Particle Astrophysics&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;div class="separator" style="clear: both; text-align: center;"&gt;&lt;a href="http://www.nasa.gov/mission_pages/kepler/multimedia/images/kepler-multi-systems_jan_2012.html" style="background-color: #d6d6d6; border-bottom-width: 0px; border-color: initial; border-image: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #004d93; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px; margin-left: 1em; margin-right: 1em; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;"&gt;&lt;img align="Bottom" alt="The image shows an overhead view of orbital positions of the planets in systems with multiple transiting planets discovered by NASA's Kepler mission." border="0" height="300" src="http://www.nasa.gov/images/content/618700main_kepler-multi-systems_4x3_226-170.jpg" style="border-bottom-style: none; border-color: initial; border-image: initial; border-left-color: rgb(0, 0, 0); border-left-style: none; border-right-color: rgb(0, 0, 0); border-right-style: none; border-top-color: rgb(0, 0, 0); border-top-style: none; border-width: initial; display: block; margin-bottom: 0px; margin-left: 1px; margin-right: 5px; margin-top: 0px;" title="The image shows an overhead view of orbital positions of the planets in systems with multiple transiting planets discovered by NASA's Kepler mission." width="400" /&gt;&lt;/a&gt;&lt;/div&gt;&lt;span style="background-color: #d6d6d6; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;&lt;/span&gt;&lt;b style="background-color: #d6d6d6; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;Kepler's Planetary Systems' Orbits&lt;/b&gt;&lt;span style="background-color: #d6d6d6; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;: The image shows an overhead view of orbital positions of the planets in systems with multiple transiting planets discovered by NASA's Kepler mission.&amp;nbsp;&lt;/span&gt;&lt;br /&gt;&lt;span style="background-color: #d6d6d6; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;Image credit: NASA Ames/Dan Fabrycky, University of California, Santa Cruz&lt;/span&gt; &lt;br /&gt;&lt;span style="color: #2e2e2e; font-family: Arial, Helvetica, sans-serif;"&gt;&lt;span style="font-size: 12px; line-height: 18px;"&gt;&lt;br /&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;br /&gt;Planetary systems with TTVs can be verified without requiring extensive ground-based observations, accelerating confirmation of planet candidates. The TTV detection technique also increases Kepler's ability to confirm planetary systems around fainter and more distant stars.&lt;br /&gt;&lt;br /&gt;“By precisely timing when each planet transits its star, Kepler detected the gravitational tug of the planets on each other, clinching the case for ten of the newly announced planetary systems,” said Dan Fabrycky, Hubble Fellow at the University of California, Santa Cruz and lead author for a paper confirming Kepler-29, 30, 31 and 32."&lt;br /&gt;&lt;br /&gt;Five of the systems (Kepler-25, Kepler-27, Kepler-30, Kepler-31 and Kepler-33) contain a pair of planets where the inner planet orbits the star twice during each orbit of the outer planet. Four of the systems (Kepler-23, Kepler-24, Kepler-28 and Kepler-32) contain a pairing where the outer planet circles the star twice for every three times the inner planet orbits its star.&lt;br /&gt;&lt;br /&gt;“These configurations help to amplify the gravitational interactions between the planets, similar to how my sons kick their legs on a swing at the right time to go higher,” said Jason Steffen, the Brinson postdoctoral fellow at Fermilab Center for Particle Astrophysics in Batavia, Ill., and lead author of a paper confirming Kepler-25, 26, 27 and 28.&lt;br /&gt;&lt;br /&gt;The system with the most planets among these discoveries is Kepler-33, a star that is older and more massive than our sun. Kepler-33 hosts five planets, ranging in size from 1.5 to 5 times that of Earth and all located closer to their star than any planet is to the sun.&lt;br /&gt;&lt;br /&gt;The properties of a star provide clues for planet detection. The decrease in the star's brightness and duration of a planet transit combined with the properties of its host star present a recognizable signature. When astronomers detect planet candidates that exhibit similar signatures around the same star the likelihood of any of these planet candidates being a false positive is very low.&lt;br /&gt;&lt;br /&gt;“The approach that was used to verify the Kepler-33 planets shows that the overall reliability of Kepler's candidate multiple transiting systems is quite high," said Jack Lissauer, planetary scientist at NASA Ames Research Center at Moffett Field, Calif., and lead author of the paper confirming Kepler-33. “This is a validation by multiplicity.”&lt;br /&gt;&lt;br /&gt;These discoveries are published in the Astrophysical Journal and the Monthly Notices of the Royal Astronomical Society and can be viewed at:&lt;br /&gt;J Lissauer et al - Almost All of Kepler's Multiple Planet Candidates are Planets, and Kepler-33 5-planet system&lt;br /&gt;E Ford et al - Transit Timing Observations from Kepler: II. Confirmation of Two Multiplanet Systems via a Non-parametric Correlation Analysis. Confirms KOI-168=Kepler-23 and KOI 1102=Kepler-24&lt;br /&gt;J Steffen et al - Transit Timing Observations from Kepler: III. Confirmation of 4 Multiple Planet Systems by a Fourier-Domain Study of Anti-correlated Transit Timing Variations&lt;br /&gt;D Fabrycky et al - Transit Timing Observations From Kepler: IV. Confirmation Of 4 Multiple Planet Systems By Simple Physical Models&lt;br /&gt;Ames Research Center in Moffett Field, Calif., manages Kepler's ground system development, mission operations and science data analysis. NASA’s Jet Propulsion Laboratory, Pasadena, Calif., managed the Kepler mission's development.&lt;br /&gt;&lt;br /&gt;Ball Aerospace and Technologies Corp. in Boulder, Colo., developed the Kepler flight system and supports mission operations with the Laboratory for Atmospheric and Space Physics at the University of Colorado in Boulder.&lt;br /&gt;&lt;br /&gt;The Space Telescope Science Institute in Baltimore archives, hosts and distributes Kepler science data. Kepler is NASA's 10th Discovery Mission and is funded by NASA's Science Mission Directorate at the agency's headquarters in Washington.&lt;br /&gt;&lt;br /&gt;For more information about the Kepler mission, visit: http://www.nasa.gov/kepler&lt;br /&gt;&lt;br /&gt;&lt;/div&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;object&gt;  &lt;script src="http://media.vmixcore.com/vmixcore/embed?action=Media&amp;amp;ver=2.0&amp;amp;method=js&amp;amp;output=string&amp;amp;auto_play=0&amp;amp;player_id=127b4c33dad65bec1766de09e747bf8d&amp;amp;t=V0RpwdRopDaOKS67ffkNe9xUCISmP-RxaP&amp;amp;width=440&amp;amp;height=279" type="text/javascript"&gt;&lt;/script&gt;  &lt;/object&gt;&lt;br /&gt;&lt;br /&gt;&lt;b style="background-color: #e4e4e4; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;Kepler's Planetary Systems in Motion&lt;/b&gt;&lt;span style="background-color: #e4e4e4; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;: The animation shows an overhead view of the orbital position of the planets in systems with multiple transiting planets discovered by NASA's Kepler mission. All the colored planets have been verified. More vivid colors indicate planets that have been confirmed by their gravitational interactions with each other or the star. Several of these systems contain additional planet candidates (shown in grey) that have not yet been verified.&amp;nbsp;&lt;/span&gt;&lt;br /&gt;&lt;span style="background-color: #e4e4e4; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;Image credit: NASA Ames/Dan Fabrycky, University of California, Santa Cruz&lt;/span&gt; &lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;object&gt; &lt;script type="text/javascript" src="http://media.vmixcore.com/vmixcore/embed?action=Media&amp;ver=2.0&amp;method=js&amp;output=string&amp;auto_play=0&amp;player_id=127b4c33dad65bec1766de09e747bf8d&amp;t=V0ygNOrtujyekx8dkBTSJTJw7dMpMguhsC&amp;width=440&amp;height=279"&gt;&lt;/script&gt; &lt;/object&gt;&lt;br /&gt;&lt;br /&gt;&lt;b style="background-color: #e4e4e4; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;Transit Timing Variations&lt;/b&gt;&lt;span style="background-color: #e4e4e4; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;: The animation shows the difference between planet transit timing of single and multiple planet system. In tightly packed planetary systems, the gravitational pull of the planets among themselves causes one planet to accelerate and another planet to decelerate along its orbit. The acceleration causes the orbital period of each planet to change. Kepler detects this effect by measuring the change known as Transit Timing Variations (TTVs).&lt;/span&gt;&lt;br /&gt;&lt;span style="background-color: #e4e4e4; color: #2e2e2e; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"&gt;Image credit: NASA Ames/Kepler mission&lt;/span&gt; &lt;/div&gt;&lt;div class="blogger-post-footer"&gt;&lt;img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/7847357309347623251-394775663521839982?l=genrepair.blogspot.com' alt='' /&gt;&lt;/div&gt;</content><link rel='replies' type='application/atom+xml' href='http://genrepair.blogspot.com/feeds/394775663521839982/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://genrepair.blogspot.com/2012/01/nasas-kepler-announces-11-planetary.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/7847357309347623251/posts/default/394775663521839982'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/7847357309347623251/posts/default/394775663521839982'/><link rel='alternate' type='text/html' href='http://genrepair.blogspot.com/2012/01/nasas-kepler-announces-11-planetary.html' title='NASA&apos;s Kepler Announces 11 Planetary Systems Hosting 26 Planets'/><author><name>Jane Shawn</name><uri>http://www.blogger.com/profile/10202717642174609796</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='http://img2.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-7847357309347623251.post-3514751047608615531</id><published>2011-11-11T01:32:00.001-08:00</published><updated>2011-11-11T01:32:06.267-08:00</updated><title type='text'>Genomics</title><content type='html'>&lt;div dir="ltr" style="text-align: left;" trbidi="on"&gt;&lt;br /&gt;Genomics is a discipline in genetics concerning the study of the genomes of organisms. The field includes intensive efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping efforts. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome's networks.&lt;br /&gt;&lt;br /&gt;For the United States Environmental Protection Agency, "the term "genomics" encompasses a broader scope of scientific inquiry associated technologies than when genomics was initially considered. A genome is the sum total of all an individual organism's genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA (genotype), mRNA (transcriptome), or protein (proteome) levels.&lt;br /&gt;&lt;/div&gt;&lt;div class="blogger-post-footer"&gt;&lt;img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/7847357309347623251-3514751047608615531?l=genrepair.blogspot.com' alt='' /&gt;&lt;/div&gt;</content><link rel='replies' type='application/atom+xml' href='http://genrepair.blogspot.com/feeds/3514751047608615531/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://genrepair.blogspot.com/2011/11/genomics.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/7847357309347623251/posts/default/3514751047608615531'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/7847357309347623251/posts/default/3514751047608615531'/><link rel='alternate' type='text/html' href='http://genrepair.blogspot.com/2011/11/genomics.html' title='Genomics'/><author><name>Jane Shawn</name><uri>http://www.blogger.com/profile/10202717642174609796</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='http://img2.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-7847357309347623251.post-461424980384947594</id><published>2011-11-02T00:37:00.000-07:00</published><updated>2011-11-02T00:37:48.043-07:00</updated><title type='text'>Ask Genomic RepairMom...Child Birth</title><content type='html'>&lt;div dir="ltr" style="text-align: left;" trbidi="on"&gt;The genesis of this posting came from DrugMonkey's posting about home childbirth.&lt;br /&gt;&lt;br /&gt;More . . .&lt;br /&gt;&lt;a href="http://www.labspaces.net/blog/1027/Ask_Genomic_RepairMom___Child_Birth" rel="nofollow"&gt;http://www.labspaces.net/blog/1027/Ask_Genomic_RepairMom___Child_Birth&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;div dir="ltr" style="text-align: left;" trbidi="on"&gt;&lt;div class="youtube"&gt;&lt;object height="385" width="480"&gt;&lt;param name="movie" value="http://www.youtube.com/v/3yfuo3aP574?fs=1&amp;amp;hl=en_US"&gt;&lt;/param&gt;&lt;param name="allowFullScreen" value="true"&gt;&lt;/param&gt;&lt;embed src="http://www.youtube.com/v/3yfuo3aP574?fs=1&amp;amp;hl=en_US" type="application/x-shockwave-flash" allowfullscreen="true" width="480" height="385"&gt;&lt;/embed&gt;&lt;/object&gt;&lt;/div&gt;&lt;/div&gt;&lt;/div&gt;&lt;div class="blogger-post-footer"&gt;&lt;img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/7847357309347623251-461424980384947594?l=genrepair.blogspot.com' alt='' /&gt;&lt;/div&gt;</content><link rel='replies' type='application/atom+xml' href='http://genrepair.blogspot.com/feeds/461424980384947594/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://genrepair.blogspot.com/2011/11/ask-genomic-repairmomchild-birth.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/7847357309347623251/posts/default/461424980384947594'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/7847357309347623251/posts/default/461424980384947594'/><link rel='alternate' type='text/html' href='http://genrepair.blogspot.com/2011/11/ask-genomic-repairmomchild-birth.html' title='Ask Genomic RepairMom...Child Birth'/><author><name>Jane Shawn</name><uri>http://www.blogger.com/profile/10202717642174609796</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='http://img2.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-7847357309347623251.post-8641524488286774727</id><published>2011-09-19T03:47:00.000-07:00</published><updated>2011-09-19T03:47:27.667-07:00</updated><title type='text'>DNA repair</title><content type='html'>&lt;div dir="ltr" style="text-align: left;" trbidi="on"&gt;&lt;br /&gt;DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light and radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages.&lt;br /&gt;&lt;br /&gt;The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a large amount of DNA damage, or one that no longer effectively repairs damage incurred to its DNA, can enter one of three possible states:&lt;br /&gt;&lt;br /&gt;an irreversible state of dormancy, known as senescence&lt;br /&gt;&lt;br /&gt;cell suicide, also known as apoptosis or programmed cell death&lt;br /&gt;&lt;br /&gt;unregulated cell division, which can lead to the formation of a tumor that is cancerous&lt;br /&gt;&lt;br /&gt;The DNA repair ability of a cell is vital to the integrity of its genome and thus to its normal functioning and that of the organism. Many genes that were initially shown to influence life span have turned out to be involved in DNA damage repair and protection. Failure to correct molecular lesions in cells that form gametes can introduce mutations into the genomes of the offspring and thus influence the rate of evolution.&lt;br /&gt;&lt;/div&gt;&lt;div class="blogger-post-footer"&gt;&lt;img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/7847357309347623251-8641524488286774727?l=genrepair.blogspot.com' alt='' /&gt;&lt;/div&gt;</content><link rel='replies' type='application/atom+xml' href='http://genrepair.blogspot.com/feeds/8641524488286774727/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://genrepair.blogspot.com/2011/09/dna-repair.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/7847357309347623251/posts/default/8641524488286774727'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/7847357309347623251/posts/default/8641524488286774727'/><link rel='alternate' type='text/html' href='http://genrepair.blogspot.com/2011/09/dna-repair.html' title='DNA repair'/><author><name>Jane Shawn</name><uri>http://www.blogger.com/profile/10202717642174609796</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='http://img2.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry></feed>
